Biological activity and flavonoid profile of five species of the Bursera genus

Ma. Beatriz Sánchez; Ana María García; José Luis  Contreras; David Eduardo Torres; Rubén San Miguel; Patricia Guevara

doi:10.17129/botsci.2624

Ma. Beatriz Sánchez-Monroy 1Departamento de Ecología y Recursos Naturales. Facultad de Ciencias. Universidad Nacional Autónoma de México. Ciudad Universitaria, Coyoacán, CP 04510, México. https://orcid.org/0000-0002-4679-9896
Ana María García-Bores 2Laboratorio de Fitoquímica, UBIPRO, Facultad de Estudios Superiores-Iztacala. Universidad Nacional Autónoma de México, CP 54090. México https://orcid.org/0000-0002-1570-8728
José Luis Contreras-Jiménez 3Benemérita Universidad Autónoma de Puebla. 4 Sur núm. 104 Centro Histórico CP 72000. Puebla, Puebla, México https://orcid.org/0000-0002-7946-8858
David Eduardo Torres Departamento de Ecología y Recursos Naturales. Facultad de Ciencias. Universidad Nacional Autónoma de México. Ciudad Universitaria, Coyoacán, CP 04510, México. https://orcid.org/0000-0003-3711-0548
Rubén San Miguel-Chávez Laboratorio de Fitoquímica, Colegio de Postgraduados, Texcoco Estado de México, México. https://orcid.org/0000-0003-0187-5733
Patricia Guevara-Fefer Departamento de Ecología y Recursos Naturales. Facultad de Ciencias. Universidad Nacional Autónoma de México. Ciudad Universitaria, Coyoacán, CP 04510, México. https://orcid.org/0000-0003-3470-1983

DOI: https://doi.org/10.17129/botsci.2624

keywords: antibacterial, antifungal, anti-inflammatory, DPPH, leaves, stems

Abstract

Background: The genus Bursera Jacq. ex. L. concentrates its diversity in Mexico. Among the secondary metabolites that can be isolated from organic its extracts are flavonoids and lignans.

Research question: Do the biological activity of the hydroalcoholic extracts from five Bursera species studied depend on their flavonoid content?

Study site: Oaxaca, Mexico.

Methods: The extracts of B. aptera Ramírez, B. fagaroides (Kunth) Engl., B. schlechtendalii Engl., B. galeottiana Engl., B. morelensis Ramírez were analyzed by High Resolution Liquid Chromatography (HPLC) to determine their flavonoid composition. The antiradical DPPH, anti-inflammatory, antibacterial and antifungal activities of the extracts were determined.

Results: Phlorizin and quercetin were conserved in both stems and leaves of the five species studied. The phloretin was present only in the leaves of B. aptera.

The highest antibacterial activity was observed against Staphylococcus epidermidis and Salmonella typhimurium by the extracts of leaves of B. aptera (MIC 0.002 mg/mL) and the stems of B. fagaroides (MIC 0.015 mg/mL). The extract of stems of B. morelensis against Fusarium boothii presented the highest antifungal effect (lower than 50 ?g/mL). The anti-inflammatory activity of B. fagaroides was 51.24 % edema inhibition (1 mg/ear) compare to 78.76 % of indomethacin (0.358 mg/ear).

Conclusion: The presence of flavonoids in five species studied suggests the richness of these compounds in Bursera genus. The biological activities studied indicated the potential medicinal use of these species and the role that the flavonoids play in plant physiology.

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Biological activity and flavonoid profile of five species of the Bursera genus

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